璩肩墿淇濋殰
鏀粯鏂瑰紡
閰嶉€佹湇鍕�(w霉)
鍞悗鏈嶅嫏(w霉)
闂�(gu膩n)浜庢垜鍊�
绱㈢７甯冮煁缍笗浠栭煁鐗囩殑鎺ㄨ枽鍔戞渶鐐烘瘡鏃ヤ竴娆★紝姣忔鍙ｆ湇涓€鐗�锛岄毃椋熺墿鎴栦笉闅ㄩ鐗╂湇鐢�(鍙冭[钘ヤ唬鍕�(d貌ng)鍔涘(xu茅)])銆傛參鎬т笝鑲濇偅鑰呮噳(y墨ng)瑭插湪閱�(y墨)鐢熺殑鎸囧皫(d菐o)涓嬪悎鐞嗕娇鐢ㄦ湰钘ュ搧锛岃垏姝ゅ悓鏅�(sh铆)涔熸噳(y墨ng)瑭茶鍋氬ソ鍩烘湰鐨勬不鐧傚伐浣�锛屾寜鐓ч啱(y墨)鐢熺殑鍙洃鍜岃姹備締鎳�(y墨ng)灏�(du矛)鐥呯櫏銆� 瑭虫儏
涓欓€氭矙鐢ㄤ簬娌荤檪鎴愪汉鎱㈡€т笝鍨嬭倽鐐庣梾姣�(HCV)鎰熸煋?锛涢閭�?y墨ng)瑭茶閲濆皪(du矛)鎬х殑鍘婚潰灏�(du矛)鐤剧梾锛屽鍘讳簡瑙ｆ不鐧備笂鐨勮┏绱�(x矛)鍏�(n猫i)瀹癸紝鑳藉鍦ㄩ啱(y墨)鐢熺殑鎸囧皫(d菐o)涓嬪幓閬告搰鐢ㄨ棩锛屼篃鎳�(y墨ng)瑭茶┏绱�(x矛)鍦板仛濂借(h霉)鐞嗙浉闂�(gu膩n)鐨勫伐浣溿€� 瑭虫儏
涓欓€氭矙锛堢储纾峰竷闊嬬董甯曚粬闊嬬墖锛夌蹇岋細灏�(du矛)娲绘€ф垚鍒嗘垨浠讳竴璩﹀舰鍔戝嚭鐝�(xi脿n)瓒呮晱鍙嶆噳(y墨ng)銆傝垏寮�(qi谩ng)鏁圥-gD閫忓皫(d菐o)鍔戝拰寮�(qi谩ng)鏁圕YP瑾樺皫(d菐o)鍔戣伅(li谩n)鐢細寮�(qi谩ng)鏁圥-绯栬泲鐧�(P-gp)瑾樺皫(d菐o)鍔戞垨寮�(qi谩ng)鏁堢窗(x矛)鑳炶壊绱燩450(CYP)瑾樺皫(d菐o)鍔戦钘ュ搧?锛涢鍜€垛拋鑶簃鐣�(d膩ng)浼戞伅锛屽嬁閬庡害鍕炵疮锛屾帉鎻″嫊(d貌ng)闈滅祼(ji茅)鍚�锛屼紤鎭ソ鏈夊埄浜庣柌鍕炵殑鎭㈠京(f霉)銆� 瑭虫儏
钘ョ墿瑕佹纰虹殑浣跨敤锛岃€屼笝閫氭矙鐢ㄦ硶鐢ㄩ噺锛氬姂閲忥細Epclusa鐨勬帹钖﹀姂鏈€鐐烘瘡鏃ヤ竴娆★紝姣忔鍙ｆ湇涓€鐗囷紝闅ㄩ鐗╂垨涓嶉毃椋熺墿鏈嶇敤(鍙冭[钘ヤ唬鍕�(d貌ng)鍔涘(xu茅)] )锛涘鏋滃埄宸撮煁鏋楃敤浜庢偅浠ｅ劅鏈熻倽纭寲鐨勫熀鍥犲瀷3鎰熸煋鎮ｈ€�(绉绘鍓嶆垨绉绘鍚�)锛屽墖鍒╁反闊嬫灄鐨勬帹钖﹀姂閲忕偤1000/1,200 mg (灏�(du矛)浜庨珨閲�<75 kg鐨勬偅鑰�锛屽姂閲忕偤1000mg,灏�(du矛)浜庨珨閲�275 kg鐨勬偅鑰�锛屽姂閲忕偤1,200 mg);闂�(gu膩n)浜庡埄宸撮煁鏋楀姂鏈€瑾�(di脿o)鏁�锛岃珛(q菒ng)鍙冭€冨惈鍒╁反闊嬫灄钘ュ搧鐨勮檿鏂逛俊鎭€� 瑭虫儏
涓欓€氭矙锛堢储纾峰竷闊嬬董甯曚粬闊嬬墖锛夎棩鐗╃殑鍍�(ji脿)鏍煎湪涓嶅悓鍦版柟鏄笉鐩＄浉鍚岀殑锛屼笉鍚屽湴鍗€(q奴)涔熸渻(hu矛)涓€瀹氱殑鍋忓樊锛岀泭钘ュ悍寰锋▊澶ц棩鎴跨稉(j墨ng)钘ョ洠(ji膩n)灞€瑾�(r猫n)璀�锛屾瘡鍊�(g猫)绉戠祫鐨勫煼(zh铆)妤�(y猫)钘ュ斧寰炴キ(y猫)缍�(j墨ng)椹�(y脿n)璞愬瘜?锛涢鍛风矘锛曞瀣嶉獘顎愶紦鏅哄畵?锛岀敱浜庢偅鑰呯殑鑲濊嚐鍙楀埌鎼嶅涔嬪悗锛屽皪(du矛)浜庤剛鑲強绯栭鐨勯鐗╃殑鍒嗚В鑳藉姏鏈�(hu矛)鏈夋墍涓嬮檷銆� 瑭虫儏
绱㈢７甯冮煁缍笗浠栭煁鐗囩従(xi脿n)鍦ㄧ殑鍑哄敭鍍�(ji脿)鏍煎苟涓嶆槸鍏ㄥ湅绲�(t菕ng)涓€妯�(bi膩o)婧�(zh菙n)鐨�锛屼竴鑸湪涓嶅悓钘ユ埧涓嶅悓鍩庡競璩艰卜鍞児(ji脿)鏈�(hu矛)鏈変竴浜涘崁(q奴)鍒ワ紝闂�(gu膩n)浜庤棩鍝佸叿楂旀儏娉�锛屽悇浣嶅彲浠ユ娊绌哄幓鐩婅棩搴峰痉妯傚ぇ钘ユ埧鍜ㄨ灏堟キ(y猫)浜哄＋锛岄€欏钘ユ埧鏄稉(j墨ng)钘ョ洠(ji膩n)灞€瑾�(r猫n)璀夐亷鐨�銆� 瑭虫儏
涓嶅悓鐨勮棩搴楅姺鍞殑涓欓€氭矙锛堢储纾峰竷闊嬬董甯曚粬闊嬬墖锛夎棩鐗╁児(ji脿)鏍兼渻(hu矛)鏈夋墍宸垾锛屽湪鐩婅棩搴峰痉妯傚ぇ钘ユ埧璩艰棩锛屽児(ji脿)鏍煎(sh铆)鎯�锛岃純甯傚牬涓婅純鐐轰綆寤夛紝鍏烽珨浠ラ杸搴楃暥(d膩ng)澶╁敭鍍�(ji脿)鐐烘簴(zh菙n)?锛涢鍜磋哎濮旂啂闄俫锛屾噳(y墨ng)閬甸啱(y墨)鍥戜娇鐢ㄨ棩鐗╋紝淇濇寔鑹ソ蹇冩厠(t脿i)锛屽灞噳(y墨ng)澶氶棞(gu膩n)蹇冨拰瀹夋叞鎮ｈ€�銆� 瑭虫儏
涓欓€氭矙锛堢储纾峰竷闊嬬董甯曚粬闊嬬墖锛変笉鑹弽鎳�(y墨ng)锛氬湪鑷ㄥ簥鐮旂┒涓�锛岄牠鐥�銆佺柌鍕炲拰鎯″績鏄湪鎺ュ彈12鍛‥pclusa娌荤檪鐨勬偅鑰呬腑鍫�(b脿o)鍛婄殑甯歌(鐧�(f膩)鐢熺巼鈮�10锛�)鐨勬不鐧傚紩鐧�(f膩)涓嶈壇浜嬩欢?锛涢鍜€炶寲W(xu茅)鍚堢悊椋查锛屾彁渚涚嚐椁�(y菐ng)锛屽公鍔╁彈鎼嶇殑鑲濈窗(x矛)鑳炲啀鐢�锛屽皯鍚冨瀮鍦鹃鍝�锛屾笡灏戣剛鑲互鍙婄硸椤炵殑鏀濆叆锛屾垝閰�銆� 瑭虫儏
涓欓€氭矙锛堢储纾峰竷闊嬬董甯曚粬闊嬬墖锛夋帹钖﹀姂鏈€鐐烘瘡鏃ヤ竴娆�锛屾瘡娆″彛鏈嶄竴鐗囷紝闅ㄩ鐗╂垨涓嶉毃椋熺墿鏈�銆傚鏋滃埄宸撮煁鏋楃敤浜庢偅浠ｅ劅鏈熻倽纭寲鐨勫熀鍥犲瀷3鎰熸煋鎮ｈ€�锛屽墖鍒╁反闊嬫灄鐨勬帹钖﹀姂閲忕偤1000/1,200mg銆傛偅鑰呴２椋熸噳(y墨ng)娓呮贰銆佹槗娑堝寲锛屽缓璀板鍚冨瘜鍚董鐢熺礌鍜岀簴缍礌鐨勯鐗�銆� 瑭虫儏
涓欓€氭矙锛堢储纾峰竷闊嬬董甯曚粬闊嬬墖锛夋槸鑷ㄥ簥涓婅純鐐哄父鐢ㄧ殑钘ョ墿锛屽叾鍍�(ji脿)鏍煎苟涓嶆槸涓€鎴愪笉璁婄殑锛屼富瑕佽垏鍝佺墝銆佸姂鍨�銆佽(gu墨)鏍肩殑褰遍熆锛岄倓鑸囪棩鐗╂垚鍒嗐€佽棩鍝侀厤鏂规湁闂�(gu膩n)锛屽叿楂旀儏娉佸缓璀板墠寰€閱�(y墨)闄㈠挩瑭㈤啱(y墨)鐢�?锛涢鍜€垛拋鑶簃鐣�(d膩ng)浼戞伅锛岄伩鍏嶉亷搴﹀嫗绱�锛屽钩鏅�(sh铆)鍙爡(ji膩n)鎸侀仼搴︾殑閬�(y霉n)鍕�(d貌ng)锛屾彁楂樻姉鐥呯殑鑳藉姏銆� 瑭虫儏
涓欓€氭矙锛堢储纾峰竷闊嬬董甯曚粬闊嬬墖锛夌殑鍍�(ji脿)鏍煎湪涓嶅悓鍦版柟鏄笉鐩＄浉鍚岀殑锛屼笉鍚屽湴鍗€(q奴)涔熸渻(hu矛)涓€瀹氱殑鍋忓樊锛屾湁闇€瑕佺殑鎮ｈ€呭彲浠ュ埌鐩婅棩搴峰痉妯傚ぇ钘ユ埧璩艰卜銆傛偅鑰呰瀹氭湡鍒伴啱(y墨)闄㈡帴鍙楁鏌�锛屾敞鎰忛仼鐣�(d膩ng)?sh霉)鐢疯徆?锛屾妸鎻″ソ鍕�?d貌ng)鐨勫害锛屽仛鍒板嫗閫哥祼(ji茅)鍚堛€傜敓娲讳腑瑕佹敞鎰忕嚐椁�(y菐ng)鐨勬惌閰�锛屽鍚冭敩鑿�銆佹按鏋�銆佽倝椤炪€佽泲濂堕绛�銆� 瑭虫儏
绱㈢７甯冮煁缍笗浠栭煁鐗囩敤浜庢不鐧傛垚浜烘參鎬т笝鍨嬭倽鐐庣梾姣�(HCV)鎰熸煋锛岀敱浜庢瘡鍊�(g猫)鍦板崁(q奴)鐨勯啱(y墨)淇濇斂绛栦笉鍚岋紝鍥犳鍫�(b脿o)閵风殑姣斾緥涔熷苟涓嶄竴妯�锛屾秷璨�(f猫i)鑰呭彲浠ュ埌鐣�(d膩ng)?sh霉)姘愬凹t(y墨)淇濋儴闁€鍏烽珨鍜ㄨ銆傚叾娆″湪涓嶅悓鐨勫钩鑷�(t谩i)璩艰卜锛屽牨(b脿o)閵风殑姣斾緥涔熷苟涓嶄竴妯�锛岄倓鏈夊彲鑳芥渻(hu矛)鍙楀埌涓€浜涗繚闅�(xi菐n)鐨勫奖闊�锛屽洜姝ゆ瘡鍊�(g猫)娑堣不(f猫i)鑰呯殑瀵�(sh铆)闅涙敮浠樿不(f猫i)鐢ㄦ湁寰堝ぇ宸垾銆� 瑭虫儏
绱㈢７甯冮煁缍笗浠栭煁鐗囦富瑕佺敤浜庢不鐧傛垚浜烘參鎬т笝鍨嬭倽鐐庣梾姣掞紙HCV锛夋劅鏌�銆傜敱浜庝笝鑲濇槸涓€绋潪甯稿毚(y谩n)閲嶇殑鐤剧梾锛屼笖鑳藉鐢ㄤ簬鐩搁棞(gu膩n)鐤剧梾鐨勯啱(y墨)鐧傝硣婧愮浉灏�(du矛)绋€缂猴紝鍦ㄦ暣楂旂挵(hu谩n)澧冪殑褰遍熆涓�锛岃┎钘ョ墿鐨勫児(ji脿)鏍兼渻(hu矛)姣旇純楂�?锛涢鍜磋皯瑜備箞鎬傚笩r(sh铆)锛屾噳(y墨ng)鍤�(y谩n)鏍奸伒寰啱(y墨)鐢熺殑寤鸿锛屽悓鏅�(sh铆)涔熷彲闂�(gu膩n)娉ㄩ啱(y墨)淇濇斂绛栫瓑锛屼互娓涜紩缍�(j墨ng)婵�(j矛)璨�(f霉)鎿�(d膩n)銆� 瑭虫儏
涓欓€氭矙锛堢储纾峰竷闊嬬董甯曚粬闊嬬墖锛夌蹇岋細灏�(du矛)娲绘€ф垚鍒嗘垨浠讳竴璩﹀舰鍔戝嚭鐝�(xi脿n)瓒呮晱鍙嶆噳(y墨ng)銆傝垏寮�(qi谩ng)鏁圥-gD閫忓皫(d菐o)鍔戝拰寮�(qi谩ng)鏁圕YP瑾樺皫(d菐o)鍔戣伅(li谩n)鐢細寮�(qi谩ng)鏁圥-绯栬泲鐧�(P-gp)瑾樺皫(d菐o)鍔戞垨寮�(qi谩ng)鏁堢窗(x矛)鑳炶壊绱燩450(CYP)瑾樺皫(d菐o)鍔戦钘ュ搧銆傛偅鑰呮噳(y墨ng)澶氭敞鎰忎紤鎭�锛岀梾鎯呭ソ杞�(zhu菐n)鏅�(sh铆)鍙€�(j矛n)琛岄仼鐣�(d膩ng)?sh霉)鍊猏(y霉n)鍕�(d貌ng)鍜屽嫗鍕�(d貌ng)锛屼絾瑕佹敞鎰忓嫗閫哥祼(ji茅)鍚�銆� 瑭虫儏
涓欓€氭矙鍏掔鐢ㄨ棩鏄皻鏈⒑瀹欵pelusa鍦ㄥ厭绔ュ強18姝蹭互涓嬮潚灏戝勾涓殑瀹夊叏鎬у拰鐧傛晥銆傚皻鐒″彲鐢ㄦ暩(sh霉)鎿�(j霉)銆傛不鐧傛參鎬т笝鍨嬭倽鐐庣殑钘ョ墿绋绻佸锛屼絾鏄繀闋堝湪閱�(y墨)鐢熸寚灏�(d菐o)涓嬩娇鐢�?锛涢鍜斿舰楣卞瓡鍖堝睛骞撹瀭S鎰忔洿鏀瑰姂閲�锛屼互鍏嶇敘(ch菐n)鐢熻€愯棩鎬ф垨鍔犻噸鑲濊嚐璨�(f霉)鎿�(d膩n)銆� 瑭虫儏
涓欓€氭矙鍗崇储纾峰竷闊嬬董甯曚粬闊嬬墖锛屾槸涓€绋京(f霉)鏂瑰埗鍔�銆傚叾绲勪唤鐐烘瘡鐗囧惈 400mg 绱㈢７甯冮煁鍜� 100mg 缍笗浠栭煁銆傚皪(du矛)浜庝娇鐢ㄤ笝閫氭矙鐨勬偅鑰呬締瑾�锛屽湪骞虫檪(sh铆)鐢熸椿涓噳(y墨ng)娉ㄦ剰澶氫紤鎭�銆傜暥(d膩ng)鐥呮儏鍤�(y谩n)閲嶆檪(sh铆)锛屾洿闇€鑷ュ簥浼戞伅锛岄€欐ǎ鍙互澧炲姞鑲濊嚐鐨勮娴侀噺锛岄檷浣庤韩楂旂殑浠ｈ瑵鍔�锛屾湁鍔╀簬淇冮€�(j矛n)鑲濈窗(x矛)鑳炵殑淇京(f霉)銆� 瑭虫儏
涓欓€氭矙锛堢储纾峰竷闊嬬董甯曚粬闊嬬墖锛夎(gu墨)鏍兼槸(400mg/100mg)*28鐗�*1鐡舵瘡鐗囧惈400mg绱㈢７甯冮煁鍜�100mg缍笗浠栭煁锛屽(sh铆)闅涘児(ji脿)鏍间互鍜ㄨ?y艒u)闂�?zh菙n)锛屽姛鑳戒富娌伙細鏈搧鐢ㄤ簬娌荤檪鎴愪汉鎱㈡€т笝鍨嬭倽鐐庣梾姣�(HCV)鎰熸煋(鍙冭[鐢ㄦ硶鐢ㄩ噺]銆乕娉ㄦ剰浜嬮爡(xi脿ng)]鍜孾钘ョ悊姣掔悊])銆� 瑭虫儏
涓欓€氭矙锛堢储纾峰竷闊嬬董甯曚粬闊嬬墖锛夎(gu墨)鏍兼槸(400mg/100mg)*28鐗�*1鐡�锛屽姛鑳戒富娌伙細鏈搧鐢ㄤ簬娌荤檪鎴愪汉鎱㈡€т笝鍨嬭倽鐐庣梾姣�(HCV)鎰熸煋(鍙冭[鐢ㄦ硶鐢ㄩ噺]銆乕娉ㄦ剰浜嬮爡(xi脿ng)]鍜孾钘ョ悊姣掔悊])銆� 瑭虫儏
涓欓€氭矙锛堢储纾峰竷闊嬬董甯曚粬闊嬬墖锛夋湁绂佸繉锛屽皪(du矛)娲绘€ф垚鍒嗘垨浠讳竴璩﹀舰鍔戝嚭鐝�(xi脿n)瓒呮晱鍙嶆噳(y墨ng)鑰呯鐢�銆備笖鑱�(li谩n)鍚堢敤钘ュ彲鑳介檷浣庣储纾峰竷闊嬫垨缍笗浠栭煁鐨勮婕挎績搴﹁嚧鍏跺け鏁�銆傛參鎬т笝鍨嬭倽鐐庢偅鑰呯敤钘ュ墠鍕�(w霉)蹇呭挩瑭㈠皥妤�(y猫)閱�(y墨)鐢�銆� 瑭虫儏
姝ｅ搧淇濋殰 鏀惧績閬歌臣
鐢ㄨ棩鍏ㄧ▼鎸囧皫(d菐o)
寤犲鎺堟瑠(qu谩n) 姝ｅ搧娓犻亾
瀹夊叏鏀惧績 闅辩閰嶉€�
