璩肩墿淇濋殰
鏀粯鏂瑰紡
閰嶉€佹湇鍕�(w霉)
鍞悗鏈嶅嫏(w霉)
闂�(gu膩n)浜庢垜鍊�
娉板崥缍紙闃块仈(d谩)鏈ㄥ柈鎶楁敞灏勬恫锛夌敤娉曠敤閲忔噳(y墨ng)鍦ㄥぇ鑵垮墠閮ㄦ垨涓嬭吂閮ㄦ敞灏�銆傚湪姣忔娉ㄥ皠鏅�(sh铆)閬告搰涓嶅悓鐨勯儴浣�锛屼笉瑕佸湪鐤肩棝銆佹筏闈�銆佺櫦(f膩)绱�銆佺櫦(f膩)纭�銆佹湁鐦㈢棔鎴栧濞犵磱鐨勭毊鑶氬崁(q奴)鍩熸敞灏�銆傛偅鑰呰娉ㄦ剰鍋氬ソ淇濇殩鎺柦锛岄伩鍏嶈韩楂斿彈瀵掑彈娑�锛屽彲浠ラ仼鐣�(d膩ng)鍋氫竴浜涘悍寰�(f霉)閸涚厜銆� 瑭虫儏
鐢插挤(qi谩ng)榫嶏紙娉ㄥ皠鐢ㄧ敳娼戝凹榫嶇惀鐝€閰搁垑锛夌敤娉曠敤閲忥細浣滅偤灏嶇敓鍛芥(g貌u)鎴愬▉鑴呯殑鎯呮硜鐨勮紨鍔╄棩鐗╂檪(sh铆)锛屾帹钖﹀姂閲忕偤30mg/kg锛屾噳(y墨ng)鑷冲皯鐢�30鍒嗛悩闈滆剤娉ㄥ皠銆傛偅鑰呭钩鏅�(sh铆)瑕佸仛濂介棞(gu膩n)绡€(ji茅)閮ㄤ綅鐨勮(h霉)鐞�锛屼笉瑕侀暦鏅�(sh铆)闁撲繚鎸佷竴鍊�(g猫)濮垮嫝锛岃瀹氭檪(sh铆)鐨勯€�(j矛n)琛岄棞(gu膩n)绡€(ji茅)娲诲嫊(d貌ng)锛屽彲浠ラ€氶亷鐔辨暦绛夋柟娉曚締鑸掔珐涓嶉仼銆� 瑭虫儏
钘ュ搧鐨勬垚鍒嗕互鍙婄壒鎬т笉鍚�锛屾不鐧傜殑灏嶈薄涔熷苟涓嶄竴妯�锛岀敤浜庡瓡濠︾殑鐙€娉佷篃骞朵笉鐩稿悓銆傚瓡濠︺€佹偅铏曞眬閮ㄧ毊鑶氱牬鎼嶈€呭強灏嶆湰鍝侀亷鏁忚€呭繉鐢ㄥ京(f霉)鏂圭传鑽婃秷鍌峰反甯冭啅銆� 瑭虫儏
淇″繀鍙兘淇濋亷閲忓緢鍙兘灏�(d菐o)鑷次�2-鍙楅珨婵€鍕�(d貌ng)鍔戠殑鍏稿瀷琛ㄧ従(xi脿n)锛氶渿椤€侀牠鐥�銆佸績鎮�锛屽柈鍊�(g猫)鐥呬緥鍫�(b脿o)鍛婄殑鐧ョ媭鏈夊績鍕�(d貌ng)閬庨€燂紝楂樼硸琛€鐧�锛屼綆閴€琛€鐧ワ紝QTc寤堕暦锛屽績寰嬪け甯�锛屾儭蹇冨拰鍢斿悙锛涘彲绲︿簣鏀寔娌荤檪鍜屽皪鐧ユ不鐧傘€傚摦鍠樼梾浜哄彲浠ュ湪韬珨鐧ョ媭鍑虹従(xi脿n)浠ュ悗鍙婃檪(sh铆)鍒伴啱(y墨)闄㈠幓灏辫ê缍�(j墨ng)閬庨啱(y墨)鐢熻⿻浼颁締閬告搰钘ョ墿閫�(j矛n)琛屼娇鐢�銆� 瑭虫儏
寰�(f霉)鏂圭传鑽婃秷鍌峰反甯冭啅鐢ㄤ簬姘ｆ化琛€鐦€涔嬫€ユ參鎬ц粺绲勭箶鎼嶅偡銆傛钘ュ搧鐨勬不鐧傝〃鐝�(xi脿n)鑲畾鏄湁鍊�(g猫)楂斿樊鐣扮殑锛屼篃鏈夊彲鑳芥渻(hu矛)寮曡捣绱呰叓鐤肩棝绛夌櫏鐙€锛屼篃鏈夊彲鑳芥渻(hu矛)寮曡捣鐨柟绛夐亷鏁忓弽鎳�(y墨ng)銆� 瑭虫儏
鍩烘湰涓婃瘡鍊�(g猫)钘ュ搧閮藉彲鑳芥渻(hu矛)鏈夊壇浣滅敤锛屾牴鎿�(j霉)瑾槑鏇哥殑鍏�(n猫i)瀹瑰彲浠ョ煡閬撴钘ュ搧鐨勫壇浣滅敤鐩稿皪杓冨皯銆傚京(f霉)鏂圭传鑽婃秷鍌峰反甯冭啅瑾槑鏇镐腑鐨勪笉鑹弽鎳�(y墨ng)锛氬伓瑕嬪眬閮ㄧ毊鑶氱槞鐧紝鍋滆棩鍚庡彲鑷娑堝け銆� 瑭虫儏
婊呰弻娉ㄥ皠鐢ㄦ按钘ョ墿鐨勫児(ji脿)鏍煎湪涓嶅悓鍦版柟鏄笉鐩＄浉鍚岀殑锛屼笉鍚屽湴鍗€(q奴)涔熸渻(hu矛)涓€瀹氱殑鍋忓樊锛屽湪缍�(w菐ng)涓婅棩鎴跨泭钘ュ悍寰锋▊澶ц棩鎴胯臣钘ュ児(ji脿)鏍煎劒(y艒u)鎯�锛岀泭钘ュ悍寰锋▊澶ц棩鎴挎槸鍦嬪姝ｈ(gu墨)瀹樼恫(w菐ng)钘ュ簵?锛涢鍜傜秿r(sh铆)瑕侀(y菐ng)鎴愯壇濂界殑鐢熸椿缈�(x铆)鎱ｏ紝娉ㄦ剰澶氫紤鎭�锛岄伩鍏嶉亷搴︾殑鐔锛屼笉瑕佽畵韬珨閬庡害鍕炵疮銆� 瑭虫儏
涓嶅悓鐨勮棩搴楅姺鍞殑钘ョ墿鍍�(ji脿)鏍兼渻(hu矛)鏈夋墍宸垾锛屾偅鑰呰娉ㄦ剰鍒版瑕�(gu墨)鐨勮棩搴楄臣璨风敳寮�(qi谩ng)榫嶏紙娉ㄥ皠鐢ㄧ敳娼戝凹榫嶇惀鐝€閰搁垑锛夛紝鍏烽珨浠ラ杸搴楃暥(d膩ng)澶╁敭鍍�(ji脿)鐐烘簴(zh菙n)銆傛偅鑰呭钩鏅�(sh铆)鍙互閬╃暥(d膩ng)鍋氫簺鎴跺閬�(y霉n)鍕�(d貌ng)澶氶崨鐓夎韩楂�锛屼絾瑕侀伕鎿囬仼鍚堢殑寮�(qi谩ng)搴︼紝閬垮厤閬庡害鐨勫嫗绱�锛岄仼鐣�(d膩ng)?sh霉)鑵绘喕鎹樿粚铔熼蔼?qi谩ng)鑲岃倝鐨勫姏閲忋€� 瑭虫儏
娉板崥缍紙闃块仈(d谩)鏈ㄥ柈鎶楁敞灏勬恫锛夐仼鎳�(y墨ng)鐧ワ細椤為ⅷ(f膿ng)婵曢棞(gu膩n)绡€(ji茅)鐐�銆傛湰鍝佽垏鐢叉皑铦跺懁鍚堢敤锛岀敤浜庢不鐧傦細灏嶆敼鍠勭梾鎯呮姉棰�(f膿ng)婵曡棩锛圖MARDs)锛屽寘鎷敳姘ㄨ澏鍛ょ檪鏁堜笉浣崇殑鎴愬勾涓噸搴︽椿鍕�(d貌ng)鎬ч棰�(f膿ng)婵曢棞(gu膩n)绡€(ji茅)鐐庢偅鑰�銆傛偅鑰呭钩鏅�(sh铆)瑕佹敞鎰忓仛濂戒繚鏆栨帾鏂�锛岄伩鍏嶈韩楂斿彈瀵掑彈娑�銆� 瑭虫儏
鏂芥矝鐗癸紙鐜荤拑閰搁垑娉ㄥ皠娑诧級涓嶈壇鍙嶆噳(y墨ng)锛氬€�(g猫)鍒ユ偅鑰呮敞灏勯儴浣嶅彲鍑虹従(xi脿n)鐤肩棝銆佺毊鐤�銆佺槞鐧㈢瓑鐧ョ媭锛屼竴鑸�2-3澶╁収(n猫i)鍙嚜琛屾秷澶�锛岃嫢鐧ョ媭鎸佺簩(x霉)涓嶉€€锛屾噳(y墨ng)鍋滄鐢ㄨ棩锛岄€�(j矛n)琛屽繀瑕佺殑铏曠悊銆傛偅鑰呭钩鏅�(sh铆)鍙互浣跨敤鐔辨瘺宸炬斁鍦ㄨ偐鑶€閮ㄤ綅锛岃兘澶犱績閫�(j矛n)琛€娑插惊鐠�(hu谩n)锛屾笡杓曡偐閮ㄧ値鐧ュ拰鑲岃倝绶婂嫉鐨勭従(xi脿n)璞�銆� 瑭虫儏
寰楁柉鑺紙娉ㄥ皠鐢ㄧ敳纾洪吀鍘婚惖鑳猴級钘ョ墿鐨勫児(ji脿)鏍煎湪涓嶅悓鍦版柟鏄笉鐩＄浉鍚岀殑锛屼笉鍚屽湴鍗€(q奴)涔熸渻(hu矛)涓€瀹氱殑鍋忓樊锛岀泭钘ュ悍寰锋▊澶ц棩鎴跨稉(j墨ng)钘ョ洠(ji膩n)灞€瑾�(r猫n)璀夛紝姣忓€�(g猫)绉戠祫鐨勫煼(zh铆)妤�(y猫)钘ュ斧寰炴キ(y猫)缍�(j墨ng)椹�(y脿n)璞愬瘜?锛涢鍜傜秿r(sh铆)瑕佹敞鎰忓浼戞伅锛岄伩鍏嶈韩楂旈亷搴﹀嫗绱�銆� 瑭虫儏
瀹変桨璜捐鏄庢浉鐢ㄦ硶鐢ㄩ噺锛氭垚浜猴紙18-64姝诧級锛岄棰�(f膿ng)婵曟€ч棞(gu膩n)绡€(ji茅)鐐�銆佸挤(qi谩ng)鐩存€ц剨鏌辩値銆侀妧灞戠梾鎺ㄨ枽鍔戦噺鐐�25mg姣忓懆浜屾锛堥枔闅�72-96灏忔檪(sh铆)锛�锛涜€佸勾鎮ｈ€咃紙鈮�65姝诧級鐒￠渶閫�(j矛n)琛屽姂閲忚(di脿o)鏁�锛岀敤娉曠敤閲忚垏18-64姝茬殑鎴愪汉鐩稿悓锛涜倽鑵庡姛鑳芥悕瀹崇殑鎮ｈ€呯劇闇€閫�(j矛n)琛屽姂閲忚(di脿o)鏁�锛涘畨浣拌鐨勬敞灏勯儴浣嶇偤澶ц吙銆佽吂閮ㄥ拰涓婅噦锛屾敞灏勬柟寮忕偤鐨笅娉ㄥ皠锛涙瘡娆″湪涓嶅悓閮ㄤ綅娉ㄥ皠锛岃垏鍓嶆娉ㄥ皠閮ㄤ綅鑷冲皯鐩歌窛3cm銆� 瑭虫儏
寮�(qi谩ng)鍏嬬敓鐗╁埗鍔戜綔鐢ㄦ(j墨)鍒舵槸绔剁埈鎬у湴鑸嘥NF绲�(ji茅)鍚�锛岄樆姝NF鑸囩窗(x矛)鑳炶〃闈NF鍙楅珨鐨勭祼(ji茅)鍚�锛屾姂鍒禩NF鐨勭敓鐗╁(xu茅)娲绘€�锛岃€孴NF鏄(j墨)楂旇嚜鐒剁敘(ch菐n)鐢熺殑涓€绋窗(x矛)鑳炲洜瀛�锛屽弮鑸囨甯哥殑鐐庣櫏鍜屽厤鐤弽鎳�(y墨ng)锛涘皪浜庝腑搴﹀強閲嶅害寮�(qi谩ng)鐩存€ц剨鏌辩値鎴栨垚骞存偅鑰呰€岃█锛屽湪瀛樺湪鏈夌浉闂�(gu膩n)鍟忛鏅�(sh铆)锛屽彲浠ュ幓閬告搰鏈ó钘ョ墿渚嗛€�(j矛n)琛屼娇鐢紝浣嗘槸钘ョ墿鐨勫児(ji脿)鏍兼槸涓嶅浐瀹氱殑锛岃浠ュ(sh铆)闅涘挩瑭�?y艒u)闂�?zh菙n)銆� 瑭虫儏
椤為ⅷ(f膿ng)婵曟€ч棞(gu膩n)绡€(ji茅)鐐庨渶瑕佺⿳妤电敤钘ユ不鐧�锛岃€屾礇绱㈡礇鑺垑鐗囪鏄庢浉鐨勭敤娉曠敤閲忥細椋悗鍙ｆ湇锛涙參鎬х値鐧ョ柤鐥涳細鎴愪汉姣忔60mg锛�1鐗囷級锛屾瘡鏃ヤ笁娆�锛涙€ユ€х値鐧ョ柤鐥涳細闋撴湇60锝�120mg锛�1锝�2鐗囷級锛涘彲鏍规摎(j霉)骞撮健銆佺櫏鐙€閬╃暥(d膩ng)澧炴笡锛屼竴鏃ユ渶澶у姂閲忎笉瓒呴亷180mg锛�3鐗囷級銆傜敤钘ユ湡闁�锛屾偅鑰呰閬垮厤椋查厭銆� 瑭虫儏
姣忓€�(g猫)钘ュ搧鐨勪綔鐢ㄤ互鍙婄蹇屼簨闋�(xi脿ng)閮藉苟涓嶇浉鍚�锛岄€氶亷瑾槑鏇稿収(n猫i)瀹瑰彲浠ヤ簡瑙ｅ埌寰�(f霉)鏂圭传鑽婃秷鍌峰反甯冭啅鐢ㄤ簬姘ｆ化琛€鐦€涔嬫€ユ參鎬ц粺绲勭箶鎼嶅偡銆備絾鏄钘ュ搧涓嶈兘鐢ㄤ簬瀛曞│锛屼笉鑳界敤浜庢湁鍌峰彛鐨勫湴鏂�銆� 瑭虫儏
寮�(qi谩ng)鐩涳紙鐠�(hu谩n)瀛㈢礌杌熻啝鍥婏級瀛曞│鍙婂摵涔虫湡濠﹀コ鐢ㄨ棩锛氭湰钘ュ搧鍙€�(j矛n)鍏ヤ钩姹併€傚湪鏆仠鍝轰钩鏈熼枔锛屽摵涔虫湡濠﹀コ鍙互閬告搰浣跨敤鍏朵粬瀹夊叏鐨勫杺椁�(y菐ng)鏂瑰紡锛屽浜哄伐鍠傞(y菐ng)绛夛紝濡傛灉瀣板厭鍦ㄦ毇鍋滃摵涔虫湡闁撳嚭鐝�(xi脿n)浠讳綍鐣板父鐧ョ媭鎴栧仴搴峰晱椤�锛屾噳(y墨ng)绔嬪嵆灏遍啱(y墨)鍜ㄨ銆� 瑭虫儏
淇″繀鍙兘淇濇湁36鍊�(g猫)鏈堢殑淇濊唱(zh矛)鏈�锛岃€岃棩鐗╄嫢浣滅偤甯歌(gu墨)缍寔娌荤檪锛屽彟閰嶅揩閫熻捣鏁堢殑鏀埃绠℃摯(ku貌)寮靛姂浣滅偤绶╄В钘�锛涘缓璀版偅鑰呬换浣曟檪(sh铆)鍊欏潎闅ㄨ韩鏀滃付鍙﹂厤鐨勫揩閫熸敮姘ｇ鎿�(ku貌)寮靛姂锛涜€屽叿楂旂殑鐢ㄦ硶鐢ㄩ噺鏄細鎴愬勾浜�(18姝插拰18姝蹭互涓�)锛�1鈥�2鍚�/娆�锛屼竴鏃�2娆�锛涙湁浜涙偅鑰呭彲鑳介渶瑕佷娇鐢ㄩ噺閬�(d谩)鍒�4鍚�/娆★紝涓€鏃�2娆�锛涢潚灏戝勾(12鈥�17姝�)锛�1鈥�2鍚�/娆�锛屼竴鏃�2娆°€� 瑭虫儏
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