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渚�(l谩i)澹櫘锛堣崏閰歌壘鍙歌タ閰炴櫘铇墖锛夎棩鐞嗕綔鐢細鑹惧徃瑗块厼鏅槶鏄簩鐠�(hu谩n)姘寲閰為(l猫i)琛嶇敓鐗╄タ閰炴櫘铇殑鍠彸鏃嬪厜瀛�(xu茅)鐣版(g貌u)楂斻€傝壘鍙歌タ閰炴櫘铇姉鎶戦儊鐥呬綔鐢ㄧ殑姗�(j墨)鍒跺彲鑳借垏鎶戝埗涓绁炵稉(j墨ng)绯荤当(t菕ng)绁炵稉(j墨ng)鍏冨皪(du矛)5-HT鐨勫啀鏀濆彇锛屽緸鑰屽寮�(qi谩ng)涓5-缇ヨ壊鑳鸿兘绁炵稉(j墨ng)鐨勫姛鑳芥湁闂�(gu膩n)銆傚湪鎮ｇ梾鏈熼枔鎮ｈ€呮噳(y墨ng)鐩￠噺淇濇寔鎰夋倕鐨勫績鎯�銆佸鍙冨姞闆嗛珨娲诲嫊(d貌ng)銆佸煿椁�(y菐ng)鑸堣叮鎰�(脿i)濂界瓑锛岄兘鏈夊姪浜庣珐瑙ｆ姂閮佺櫏鐙€锛屼篃瑕佸(xu茅)鏈�(hu矛)鑷垜瑾�(di脿o)绡€(ji茅)锛岄伩鍏嶉亷(gu貌)搴﹀鍔涘拰鐒︽叜鎯呯窉鐨勭敘(ch菐n)鐢�銆� 瑭虫儏
妯�(l猫)鍙嬫槸鑳藉鐢ㄤ簬鎶戦儊鐧ョ殑涓€鍊�(g猫)钘ョ墿锛屽湪閱�(y墨)鐢熺殑鎸囧皫(d菐o)涓嬬敤浜庣浉闂�(gu膩n)鎮ｈ€�銆傛▊(l猫)鍙嬪彛鏈嶅悗鏄撳惛鏀�,涓嶅彈鎶楅吀钘ョ墿鍜岄鐗╃殑褰辨檶锛屾竻闄ゅ崐琛版湡閫氬父鐐�24灏忔檪(sh铆),鍦ㄨ倽鑷熶唬璎�,绱�2锛呬互鍘熷舰鐢卞翱鎺掑嚭,鍏朵綑浠ヤ唬璎濈敘(ch菐n)鐗╁舰寮忓緸灏夸腑鎺掑嚭,灏戦噺鐢辩碁渚挎帓娉勩€� 瑭虫儏
璁婅壊鐨勮棩鍝佷笉鍐嶉仼鐢ㄤ簬浠讳綍鐤剧梾鐨勬不鐧傦紝涓€鑸槸鍥�?y脿n)妾玘(gu貌)鏈熸垨璁婅唱(zh矛)灏�(d菐o)鑷寸殑锛屽父瑕�(ji脿n)鐨勬儏娉佹湁瀛樻斁鏅�(sh铆)闁撻亷(gu貌)涔呮垨鑰呮矑(m茅i)鏈夋寜鐓ц姹備締(l谩i)瀵嗗皝淇濆瓨銆傝崏閰歌壘鍙歌タ閰炴櫘铇墖鐐鸿杽鑶滆。鐗�锛岄櫎鍘诲寘琛ｅ悗椤櫧鑹叉垨椤�(l猫i)鐧借壊銆� 瑭虫儏
楣介吀搴︽礇瑗挎眬鑵告憾鑶犲泭鏄彲鐢ㄤ簬鎶戦儊鐧ョ殑铏曟柟钘ョ墿锛屽苟涓旀槸渚�(l谩i)鑷簬鍦�(gu贸)澶�銆傞菇閰稿害娲涜タ姹€鑵告憾鑶犲泭鐨勮捣濮嬪姂閲忕偤40mg/鏃ワ紙20mg涓€鏃ヤ簩娆★級鑷�60mg/鏃ワ紙涓€鏃ヤ竴娆℃垨30mg涓€鏃ヤ簩娆★級锛屼笉鑰冩叜閫�(j矛n)椋熸儏娉併€� 瑭虫儏
纰抽吀閶扮珐閲嬬墖鍙敤浜庢煇浜涙姂閮佺櫏鐨勬不鐧�锛屽湪娌荤檪鏈熼枔鎳�(y墨ng)瑭蹭篃鏈夊彲鑳芥渻(hu矛)鍑虹従(xi脿n)鍓綔鐢�銆傜⒊閰搁嫲绶╅噵鐗囩缍�(j墨ng)绯荤当(t菕ng)涓嶈壇鍙嶆噳(y墨ng)鏈夐洐鎵嬬窗(x矛)闇囬～銆佽悗闈�銆佺劇(w煤)鍔�銆佸棞鐫°€佽鐗╂ā绯�銆佽叡鍙嶅皠浜㈤€�(j矛n)?锛熸ⅱ類涪鍑�?x矛)鑳炲崌楂�銆� 瑭虫儏
宸︽礇寰�(f霉)鐨勫姂閲忚(di脿o)鏁达細灏�(du矛)浜庢瘡鏃ユ湇鐢�1鐗囷紙50mg锛夌檪鏁堜笉浣宠€屽皪(du矛)钘ョ墿鑰愬彈鎬ц純濂界殑鎮ｈ€呭彲澧炲姞鍔戦噺锛屽洜鑸嶆洸鏋楃殑娑堥櫎鍗婅“鏈熺偤24灏忔檪(sh铆)锛岃(di脿o)鏁村姂閲忕殑鏅�(sh铆)闁撻枔闅斾笉鎳�(y墨ng)鐭簬1鍛�锛屾渶澶у姂閲忕偤4鐗囷紙200mg锛�/鏃�銆傚姂閲忕殑瑾�(di脿o)鏁存槸闇€瑕佸湪閱�(y墨)鐢熺殑鎸囧皫(d菐o)涓嬮€�(j矛n)琛岀殑锛岃€屾偅鑰呬篃鎳�(y墨ng)瑭茬洝鍙兘閰嶅悎閱�(y墨)鐢熺殑娌荤檪宸ヤ綔锛屾寜鐓ч啱(y墨)鍥戝拰瑕佹眰渚�(l谩i)瑕�(gu墨)鑼冨悎鐞嗙殑浣跨敤鐩搁棞(gu膩n)钘ュ搧銆� 瑭虫儏
闃跨編瀵э紙闃挎垐缇庢媺姹€鐗囷級绂佸繉锛氫箼鑲濈梾姣掓敎甯惰€�/鎮ｈ€�銆佷笝鑲濈梾姣掓敎甯惰€�/鎮ｈ€呫€佽倽鍔熻兘鎼嶅鎮ｈ€咃紙鍗宠倽纭寲鎴栨椿鍕�(d貌ng)鎬ц倽鐥呮偅鑰咃級绂佺敤锛堝弮瑕�(ji脿n)[鐢ㄦ硶鐢ㄩ噺]鍜孾娉ㄦ剰浜嬮爡(xi脿ng)]锛�銆傛姂閮佺櫏绛夌簿绁炲績鐞嗙柧鐥呯殑娌荤檪闇€瑕佺簿纰虹殑瑷烘柗鍜屽€�(g猫)鎬у寲鐨勭敤钘ユ柟妗堬紝鎮ｈ€呬笉鎳�(y墨ng)鑷姹哄畾浣跨敤鍝ó钘ョ墿鎴栭毃鎰忔洿鏀圭敤钘ュ姂閲�锛屼互鍏嶅紩鐧�(f膩)涓嶅繀瑕佺殑棰�(f膿ng)闅�(xi菐n)鎴栧姞閲嶇櫏鐙€銆� 瑭虫儏
蹇冮仈(d谩)鎮咃紙姘捍閰镐紡纭タ姹€鐗囷級绂佸繉:灏�(du矛)鏈棩鍝佺殑娲绘€ф垚鍒嗘垨浠讳竴杓旀枡閬�(gu貌)鏁忕殑鎮ｈ€呯鐢�銆傜姝㈣垏闈為伕鎿囨€у柈鑳烘哀鍖栭叾鎶戝埗鍔戯紙MAOIs锛夋垨閬告搰鎬у柈鑳烘哀鍖栭叾A(MAO-A)鎶戝埗鍔戣伅(li谩n)鐢紙鍙冭(ji脿n)[钘ョ墿鐩镐簰浣滅敤]锛夈€傛湇鐢ㄩ亷(gu貌)绋嬩腑锛屾偅鑰呮噳(y墨ng)瀵嗗垏闂�(gu膩n)娉ㄨ嚜宸辩殑韬珨鍙嶆噳(y墨ng)锛屽鍑虹従(xi脿n)涓嶉仼鎴栫暟甯哥櫏鐙€锛屾噳(y墨ng)鍙婃檪(sh铆)灏遍啱(y墨)鍜ㄨ(x煤n)锛屾寜鐓ч啱(y墨)鐢熺殑寤鸿閰嶅悎瑾�(di脿o)鐞�锛岀洝鍙兘鍔犲揩搴峰京(f霉)閫�(j矛n)搴�銆� 瑭虫儏
宸︽礇寰�(f霉)锛堥菇閰歌垗鏇叉灄鐗囷級绂佸繉锛氭湰钘ュ搧绂佺敤浜庡皪(du矛)鑸嶆洸鏋楅亷(gu貌)鏁忚€呫€傝垗鏇叉灄绂佹鑸囧柈鑳烘哀鍖栭叾鎶戝埗鍔戯紙MAOI s锛夊悎鐢紙鍙冭(ji脿n)[钘ョ墿鐩镐簰浣滅敤]锛�銆傝垗鏇叉灄绂佹鑸囧尮鑾綂鐗瑰悎鐢紙鍙冭(ji脿n)[钘ョ墿鐩镐簰浣滅敤]锛�銆傛偅鑰呮噳(y墨ng)浠旂窗(x矛)闁辫畝瑾�(shu艒)鏄庢浉(sh奴)銆佹寜瑕�(gu墨)瀹氱敤閲忔搷浣�锛屽苟闂�(gu膩n)娉ㄦ姂閮佺櫏鐨勭梾鍥犲拰闋�(y霉)闃�銆傚悓鏅�(sh铆)锛岄伕鎿囨瑕�(gu墨)钘ュ簵濡傜泭钘ュ悍寰锋▊(l猫)澶ц棩鎴胯臣(g貌u)璨�(m菐i)钘ュ搧锛屽苟閬靛惊閱�(y墨)鐢熺殑寤鸿閫�(j矛n)琛屾不鐧傚拰搴峰京(f霉)銆� 瑭虫儏
渚�(l谩i)澹櫘锛堣崏閰歌壘鍙歌タ閰炴櫘铇墖锛変笉鑹弽鎳�(y墨ng)澶氱櫦(f膩)鐢熷湪闁�(k膩i)濮嬫不鐧傜殑绗�1-2鍛�锛屾寔绾�(x霉)娌荤檪鍚庝笉鑹弽鎳�(y墨ng)鐨勫毚(y谩n)閲嶇▼搴﹀拰鐧�(f膩)鐢熺巼閮芥渻(hu矛)闄嶄綆銆傚钩鏅�(sh铆)鎮ｈ€呭彲浠ラ伕鎿囬仼鍚堣嚜宸辩殑閬�(y霉n)鍕�(d貌ng)鏂瑰紡锛屽鏁ｆ銆佺憸浼�銆佹父娉崇瓑锛屽苟閫愭几澧炲姞閬�(y霉n)鍕�(d貌ng)寮�(qi谩ng)搴﹀拰鏅�(sh铆)闁�銆備絾闇€娉ㄦ剰锛岄亱(y霉n)鍕�(d貌ng)鏅�(sh铆)鎳�(y墨ng)閬垮厤閬�(gu貌)搴﹀嫗绱�锛屼互鍏嶅皪(du矛)韬珨閫犳垚璨�(f霉)鎿�(d膩n)銆� 瑭虫儏
鍥犻樋绔嬪搶鍞戝彛宕╃墖鍏锋湁伪1 -鑵庝笂鑵虹礌鑳藉彈楂旂殑鎷姉浣滅敤锛屽彲鑳藉紩璧烽珨浣嶆€т綆琛€澹�銆傛偅鑰呯殑鍏烽珨鎯呮硜涓嶅悓锛屽壇浣滅敤琛ㄧ従(xi脿n)绋嬪害涓嶅悓锛屾不鐧傜殑鏂规硶涔熷苟涓嶄竴妯�锛屾墍浠ユ噳(y墨ng)瑭茶鑰冩叜鎸夌収閱�(y墨)鐢熺殑瑕�(gu墨)瀹氫締(l谩i)浣跨敤钘ョ墿锛屽悓鏅�(sh铆)涔熸噳(y墨ng)瑭茶娉ㄦ剰闁辫畝钘ュ搧鐨勮(shu艒)鏄庢浉(sh奴)鍏�(n猫i)瀹�銆� 瑭虫儏
鍙湁鐣�(d膩ng)濡婂鏈熷│濂虫湇钘ョ殑鐩婅檿鏄庨’澶т簬钘ョ墿灏�(du矛)鑳庡厭鐨勬經鍦ㄩⅷ(f膿ng)闅�(xi菐n)鏅�(sh铆)锛屾柟鍙湇宸︽礇寰�(f霉)銆傛姂閮佺櫏鍦ㄤ腑鍦�(gu贸)鐨勭櫦(f膩)鐥呯巼姣旇純楂�锛屼絾鏄敱浜庡眳姘戠己涔忓皪(du矛)鍏剁殑瑾�(r猫n)璀�(sh铆)鍜屼簡瑙�锛屾墍浠ュ氨鍙兘鏈�(hu矛)瀛樺湪涓嶈兘鏃╂湡鎺ュ彈娌荤檪鐨勭従(xi脿n)璞°€� 瑭虫儏
纰抽吀閶扮珐閲嬬墖鍦ㄤ娇鐢ㄦ檪(sh铆)鏈変竴瀹氱殑闄愬埗姊濅欢锛岄儴鍒嗕汉缇や笉瀹滀娇鐢ㄦ垨闇€瑕佽(j菒n)鎱庨伕鎿�銆傜⒊閰搁嫲绶╅噵鐗囩蹇屾槸鑵庡姛鑳戒笉鍏ㄨ€�銆佸毚(y谩n)閲嶅績鑷熺柧鐥呮偅鑰呯鐢ㄣ€傚洜姝�锛屽湪钘ョ墿绂佸繉鑼冨湇涔嬪収(n猫i)鐨勪汉缇わ紝鍒囧繉鐩茬洰浣跨敤瑭茶棩鐗�銆� 瑭虫儏
纰抽吀閶扮珐閲嬬墖甯歌(ji脿n)涓嶈壇鍙嶆噳(y墨ng)鍙ｅ共銆佺叐娓淬€佸椋�銆佸灏裤€佷究绉�銆佽吂鐎�銆佹儭蹇冦€佸様鍚�銆佷笂鑵圭棝銆傚缓璀拌簛鐙傜櫏鐨勬偅鑰呰绌嶆サ鐨勯厤鍚堥啱(y墨)甯敤钘ヤ娇鐢ㄨ棩鐗�锛岃(di脿o)鐞嗚韩楂旀湡闁撹椁�(y菐ng)鎴愬ソ鐨勭敓娲荤繏(x铆)鎱�锛岃娉ㄦ剰涓嶈兘閬�(gu貌)澶氱殑鍕炵疮锛岃€屼笖閭勮澶氬仛涓€浜涢珨鑲查崨鐓�锛岄€欐ǎ鍙互娓涘皯鐤剧梾鐨勭櫦(f膩)鐢�銆� 瑭虫儏
渚�(l谩i)澹櫘鑰佸勾鐢ㄨ棩65姝蹭互涓婄殑鑰佸勾鎮ｈ€�锛屾帹钖︿互涓婅堪甯歌(gu墨)璧峰鍔戦噺鐨勫崐閲�(5mg)闁�(k膩i)濮嬫不鐧�锛屾瘡鏃ユ渶澶у姂閲忎笉鎳�(y墨ng)瓒呴亷(gu貌)10mg銆傛墍浠ヨ叇鐥呮偅鑰呭湪浣跨敤钘ョ墿鐨勬檪(sh铆)鍊欎篃瑕佹帉鎻￠€欎簺鍩烘湰淇℃伅锛屾牴鎿�(j霉)韬珨鐨勬儏娉佷締(l谩i)浣跨敤钘ョ墿寰堥噸瑕佺殑锛屽悓鏅�(sh铆)涔熻淇濊瓑鍏呰冻鐨勭潯鐪犱締(l谩i)闋�(y霉)闃茬柧鐥呯櫦(f膩)鐢�銆� 瑭虫儏
渚�(l谩i)澹櫘锛堣崏閰歌壘鍙歌タ閰炴櫘铇墖锛夋椿鎬ф垚浠斤細鑽夐吀鑹惧徃瑗块厼鏅槶銆傜敤娉曪細鍙ｆ湇锛屽彲浠ヨ垏椋熺墿鍚屾湇銆傜敤钘ヤ箣鍓嶆偅鑰呮噳(y墨ng)浠旂窗(x矛)闁辫畝钘ュ搧瑾�(shu艒)鏄庢浉(sh奴)锛屼簡瑙ｈ棩鐗╃殑閬╂噳(y墨ng)鐧�銆佺蹇岀櫏鍜屾敞鎰忎簨闋�(xi脿ng)绛変俊鎭�锛屽湪浣跨敤閬�(gu貌)绋嬩腑锛屽鍑虹従(xi脿n)浠讳綍涓嶉仼鎴栫枒浼间笉鑹弽鎳�(y墨ng)锛屾噳(y墨ng)绔嬪嵆鍋滆棩骞跺強鏅�(sh铆)灏遍啱(y墨)鍜ㄨ(x煤n)銆� 瑭虫儏
鐩＄鍏掔鎮ｈ€呭皪(du矛)宸︽礇寰�(f霉)鑸嶆洸鏋楃殑浠ｈ瑵绋嶅揩锛岀偤浜嗛伩鍏嶇敘(ch菐n)鐢熼亷(gu貌)楂樼殑琛€钘ユ績搴�锛屽皪(du矛)鍏掔鎮ｈ€呭缓璀颁娇鐢ㄨ純浣庡姂閲�锛屽挨鍏舵槸6锝�12 姝查珨閲嶈純杓曠殑鍏掔銆傛姂閮佺櫏鐨勬不鐧傞渶瑕佹牴鎿�(j霉)骞撮健鍜岀梾鎯呬締(l谩i)閫�(j矛n)琛屽垎鏋愩€傚鏋滄槸鍏掔鍑虹従(xi脿n)鎶戦儊鐧ョ殑鎯呮硜锛岄偅涔堜篃鎳�(y墨ng)瑭插湪閱�(y墨)鐢熺殑鎸囧皫(d菐o)涓嬫纰鸿檿鐞�銆� 瑭虫儏
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寰堝鎮ｈ€呴兘鐭ラ亾鍚堢悊鐢ㄨ棩鐨勯噸瑕佹€�锛屽ェ楹ュ€菇閰告盁瑗挎眬鑶犲泭鐢ㄦ硶鐢ㄩ噺鏄竴鑸彧闇€姣忓ぉ鏃╀笂涓€娆″彛鏈�20mg锛屽繀瑕佹檪(sh铆)鍙姞鑷虫瘡澶�40mg銆傚姂閲忓拰鐧傜▼閬甸啱(y墨)鍥�銆傚鏋滄偅鑰呭湪鏈嶇敤钘ョ墿鏈熼枔瀛樺湪鐤戝晱(w猫n)锛岃鍙婃檪(sh铆)灏嬫眰鍜ㄨ(x煤n)閱�(y墨)鐢熺殑鎰忚(ji脿n)銆� 瑭虫儏
渚�(l谩i)澹櫘锛堣崏閰歌壘鍙歌タ閰炴櫘铇墖锛夌蹇屾槸1.灏�(du矛)鏈棩鐗╂椿鎬ф垚浠芥垨浠讳竴杓旀枡閬�(gu貌)鏁忚€呯姝娇鐢�銆傞櫎浜嗚棩鐗╂不鐧傚拰椋查瑾�(di脿o)鐞嗭紝閭勬湁涓€浜涜紨鍔╂€х殑鏂瑰紡涔熻兘骞姪绶╄В鎶戦儊鐧ョ媭锛屽閬�(y霉n)鍕�(d貌ng)鍜屽績鐞嗘不鐧�銆傜爺绌剁櫦(f膩)鐝�(xi脿n)锛岃(gu墨)寰嬬殑鏈夋哀閬�(y霉n)鍕�(d貌ng)鑳藉鍒烘縺鍏�(n猫i)鍟¤偨鐨勫垎娉�锛屽寮�(qi谩ng)鎯呯窉鐨勬剦鎮呮劅銆傛澶�锛屽弮鑸囦竴浜涢珮寮�(qi谩ng)搴︾殑閸涚厜娲诲嫊(d貌ng)锛屽璺戞銆佹父娉崇瓑锛屼篃鑳介噵鏀惧鍔涳紝绶╄В鐒︽叜鎯呯窉銆� 瑭虫儏
姝ｅ搧淇濋殰 鏀惧績閬歌臣(g貌u)
鐢ㄨ棩鍏ㄧ▼鎸囧皫(d菐o)
寤�(ch菐ng)瀹舵巿娆�(qu谩n) 姝ｅ搧娓犻亾
瀹夊叏鏀惧績 闅辩閰嶉€�
