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鏀粯鏂瑰紡
閰嶉€佹湇鍕�(w霉)
鍞悗鏈嶅嫏(w霉)
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闂�(gu膩n)浜庤棩鍝佺殑鎴愬垎锛屼汉鍊戞噳(y墨ng)瑭茶鏈夋竻妤氱殑瑾�(r猫n)璀�(sh铆)鍜屼簡瑙ｃ€備竷鍗佸懗鐝嶇彔涓歌(shu艒)鏄庢浉(sh奴)涓湁鐩搁棞(gu膩n)鐨勪粙绱�锛屽畠鐨勬垚浠芥湁鐝嶇彔銆佹獉棣�銆侀檷棣欍€佺敇鑽�銆佸ぉ绔洪粌銆佽タ绱呰姳銆侀珨澶栧煿鑲茬墰榛�銆佷汉宸ラ簼棣�銆佺強鐟氥€佺應鐟�銆佷節鐪肩煶銆佸潗鑷�(t谩i)绛�70鍛�銆� 瑭虫儏
闂�(gu膩n)娉ㄨ棩鍝佺殑椤忚壊鍜屾€х媭锛岃兘澶犲公鍔╁強鏅�(sh铆)鐧�(f膩)鐝�(xi脿n)閬�(gu貌)鏈熸垨璁婅唱(zh矛)鍟�(w猫n)椤�锛屽彲娓涘皯涓嶆伆鐣�(d膩ng)鐢ㄨ棩琛岀偤灏�(du矛)韬珨甯朵締(l谩i)鐨勫奖闊垮拰灏�(du矛)鐤剧梾娌荤檪鐢�(ch菐n)鐢熺殑褰遍熆銆傚ェ鍗¤タ骞崇墖鐐烘泛鐏扮稜鑹诧紙0.15g锛�銆侀粌鑹诧紙0.3g锛夋垨娣虹矇绱呰壊锛�0.6g锛夋鍦撳舰钖勮啘琛ｇ墖锛岄櫎鍘昏杽鑶滆。椤櫧鑹叉垨椤�(l猫i)鐧借壊銆� 瑭虫儏
钘ョ墿閹�(zh猫n)鐥涚殑姗�(j墨)鍒惰垏鍏舵垚鍒嗘湁闂�(gu膩n)锛屾牴鎿�(j霉)瑾�(shu艒)鏄庢浉(sh奴)浠嬬垂鍙煡鐗涚棙鐤嫍鎺ョó瀹跺厰鐐庣櫏鐨啔鎻愬彇鐗╂敞灏勬恫鐨勯幃(zh猫n)鐥涗綔鐢ㄦ槸閫氶亷(gu貌)灏�(du矛)涓绁炵稉(j墨ng)绯荤当(t菕ng)鍏�(n猫i)閹�(zh猫n)鐥涙(j墨)鍒朵箣涓€鐨勪笅琛屾€ф姂鍒剁郴绲�(t菕ng)鐢�(ch菐n)鐢熺殑婵€娲讳綔鐢ㄥ緱浠ュ(sh铆)鐝�(xi脿n)鐨�銆� 瑭虫儏
鍒╁繀閫氭不鐧傜櫜鐧囨檪(sh铆)鏈夊毚(y谩n)鏍肩殑鐢ㄩ噺瑕�(gu墨)瀹氫互鍙婄敤娉曡姹傦紝鑰屾偅鑰呭繀闋堣鎸夌収灏�(du矛)鎳�(y墨ng)鐨勫師鍓囦締(l谩i)浣跨敤銆傚埄蹇呴€氫竴鏃︾櫦(f膩)鐢熻棩鐗╅亷(gu貌)閲�锛岀梾浜烘噳(y墨ng)浣忛櫌娌荤檪锛屽苟绲︿簣閬╃暥(d膩ng)?sh霉)闂剐＄粐鐓�?锛涘闇€瑕�锛�?y墨ng)閫�(j矛n)琛屾礂鑳冦€� 瑭虫儏
鐧茬檱鎮ｈ€呭湪鐢ㄨ棩鏈熼枔瑕佹敞鎰忚瀵�锛屾湁鍙兘鏈�(hu矛)鏈夊壇浣滅敤銆傚瓡濠﹀強鍝轰钩鏈熷│濂崇鐢ㄥ京(f霉)鏂硅嫰宸存瘮濡ユ捍鍖栭垑鐗�锛屽壇浣滅敤鏄瓨鍦ㄧ殑锛屾瘮濡傚€�(g猫)鍒ユ偅鑰呭彲鍑虹従(xi脿n)鐨柟锛屽墲鑴€х毊鐐�锛涘彲鍑虹従(xi脿n)鍡滅潯銆佺湬鏆�銆佸摦鍠樼櫏鐙€锛屽仠钘ュ悗涓婅堪鍙嶆噳(y墨ng)鍙嚜琛屾秷澶�锛涢亷(gu貌)閲忓彲寮曡捣鏄忕潯銆� 瑭虫儏
閮ㄥ垎鐧茬檱鎮ｈ€呭苟涓嶉渶瑕侀暦(zh菐ng)鏈熺敤钘ュ氨鑳芥帶鍒剁梾鎯�锛岃€岄瀼鍥烘不鐧傚拰鍋滄娌荤檪鏄湁涓€浜涜瑳绌剁殑銆傛牴鎿�(j霉)鐣�(d膩ng)鍓嶇殑鑷ㄥ簥瀵�(sh铆)韪愶紝濡傞渶鍋滄鏈嶇敤闁�(k膩i)娴﹁槶锛屽缓璀伴€愭几鍋滆棩銆�(渚嬪 锛氭垚浜烘瘡闅�2-4鍛�锛屾瘡娆℃笡灏�500 mg锛屾瘡鏃�2娆� 锛涘厭绔ユ噳(y墨ng)姣忛殧2鍛�锛屾瘡娆℃笡灏�10 mg/kg锛屾瘡鏃�2娆�)銆� 瑭虫儏
钘ュ搧鏄不鐧傜櫜鐧囩殑閲嶈鎺柦锛岃€屾瘡鍊�(g猫)钘ュ搧鐨勭郸钘ラ€斿緫浠ュ強浠ｈ瑵鎯呮硜閮藉苟涓嶇浉鍚岋紝閫欏氨闇€瑕佹偅鑰呭拰瀹跺爆閫氶亷(gu貌)瑾�(shu艒)鏄庢浉(sh奴)渚�(l谩i)浜嗚В銆傚乏涔欐媺瑗垮潶鐗囩郸钘ラ€斿緫 锛氬彛鏈�锛岄渶浠ラ仼閲忕殑姘村悶鏈�锛屾湇鐢ㄤ笉鍙楅€�(j矛n)椋熷奖闊�銆� 瑭虫儏
绐佺劧涓柗鎶楃櫜鐧囪棩鐗╃殑閬�(y霉n)鐢ㄦ槸寰堝嵄闅�(xi菐n)鐨勶紝濡傛灉鎮ｈ€呮兂瑕佸仠姝㈢敤钘ユ垨鏇存彌鐢ㄨ棩锛屾噳(y墨ng)瑭插湪閱�(y墨)鐢熺殑鎸囧皫(d菐o)涓嬫搷浣溿€傚痉宸撮噾鍙帶鍒剁櫜鐧囩櫦(f膩)浣�锛屽湪閭ｄ簺鐐洪爯(y霉)闃插ぇ鐧�(f膩)浣滅櫦(f膩)鐢熻€屾噳(y墨ng)鐢ㄨ棩鐗╃殑鎮ｈ€呬腑锛屼笉鎳�(y墨ng)瑭茬獊鐒跺仠鐢ㄦ姉鐧茬檱钘ョ墿锛岄€欐槸鍥�?y脿n)妲跨换顛鸿潡鐓岋极?锛屽嚭鐝�(xi脿n)浼存湁缂烘哀鍜岀敓鍛藉▉鑴呯殑鐧茬檱鎸佺簩(x霉)鐙€鎱�(t脿i)鐨勫彲鑳芥€у緢澶�銆� 瑭虫儏
鏈夎ū澶氫腑钘ユ潗鍙敤浜庣櫜鐧囨偅鑰�锛岀暥(d膩ng)鐒跺叿楂旂殑鏂规鎳�(y墨ng)瑭蹭互閱�(y墨)鐢熺殑鎸囧皫(d菐o)鎰忚(ji脿n)鐐烘簴(zh菙n)銆傜櫜鐧囧悍鑶犲泭鎴愪唤鏈夊ぉ楹�銆佺煶鑿栬挷銆佷汉宸ョ墰榛�銆佸兊锠�銆佽喗鍗楁槦銆佷汉鍙冦€侀仩(yu菐n)蹇椼€佸叏铦�銆佺惀鐝€銆佸啺鐗囩瓑15鍛�銆� 瑭虫儏
寰楃悊澶氶渶瑕佸湪瀵嗗皝鐨勬浠朵笅淇濆瓨锛屽苟涓斿湪璁婅唱(zh矛)鍜岄亷(gu貌)鏈熺殑鎯呮硜涓�锛屼笉寰楃辜绾�(x霉)鐢ㄤ簬鐧茬檱娌荤檪銆傚緱鐞嗗鐐虹‖鑶犲泭鍔�锛屽収(n猫i)瀹圭墿鐐洪粌妫曡壊鐨勭矇鏈�锛涙埃娓呴锛屽懗鑻�锛屼繚璩�(zh矛)鏈熸槸60鍊�(g猫)鏈堛€� 瑭虫儏
涓欐垔閰搁垑绶╅噵鐗囧児(ji脿)鏍兼槸瑷卞鎮ｈ€呬互鍙婂灞墍闂�(gu膩n)娉ㄧ殑锛屼絾浜嬪(sh铆)涓婂湪姣忎竴鍊�(g猫)鍦版柟鐨勫敭鍍�(ji脿)閮藉彲鑳戒笉鍚�銆備笝鎴婇吀閳夌珐閲嬬墖鏄竴绶╅噵鍒跺姂锛屾湇鐢ㄦ湰钘ュ悗楂斿収(n猫i)琛€钘ユ績搴﹀嘲鍊煎彲闄嶄綆锛屽悓鏅�(sh铆)鍙繚璀夎钘ユ績搴﹀湪24灏忔檪(sh铆)鍏�(n猫i)缍寔鍦ㄦ甯告按骞�銆� 瑭虫儏
钘ュ搧閮芥渻(hu矛)瀛樺湪闆欓潰鎬�锛屾瘮濡傛湁鍙兘鏈�(hu矛)寮曡捣鍓綔鐢�锛屽彲鑳芥渻(hu矛)灏�(d菐o)鑷翠竴浜涙經鍦ㄧ殑棰�(f膿ng)闅�(xi菐n)銆傚ぇ鑼冨湇鑷寸獊璁婃€ц│椹�(y脿n)鐨勭祼(ji茅)鏋滆〃鏄�锛屾媺鑾笁鍡墖灏�(du矛)浜洪(l猫i)鐒�(w煤)閬哄偝瀛�(xu茅)鍗遍毆(xi菐n)锛涘湪澶�銆佸皬榧犵殑闀�(zh菐ng)鏈熺爺绌朵腑锛屾媺鑾笁鍡墖鐒�(w煤)鑷寸檶鎬�銆� 瑭虫儏
閱�(y墨)鐢熼€氬父琚憡瑾℃嚪瀛曟湡闅庢鐨勫コ鎬ц(j菒n)鎱庣敤钘ワ紝鍥�?y脿n)妯舰鍒沖绔嬪濞犳湡闁撲互鍙婂摵涔虫湡闁撶郸绁炵稉(j墨ng)濡ユ▊(l猫)骞冲畨鍏ㄦ€х殑鍟�(w猫n)椤�锛屾墍浠�锛屽皪(du矛)瀛曞│銆佹湁鎳峰瓡鍙兘鐨勫│濂�锛屼互鍙婂摵涔虫湡濠﹀コ锛屽儏鍦ㄥ垽鏂锋不鐧備笂鐨勬湁鐩婃€уぇ浜庡嵄闅�(xi菐n)鎬х殑姊濅欢涓嬫柟鍙湇鐢�銆� 瑭虫儏
涓冨崄鍛崇弽鐝犱父鐢ㄦ硶鐢ㄩ噺锛氱爺纰庡悗闁�(k膩i)姘撮€佹湇锛岄噸鐥呬汉涓€鏃�1鍏嬶紙1涓革級锛涗竴鑸瘡闅�3-7澶�1鍏嬶紙1涓革級锛屾敞鎰忎簨闋�(xi脿ng)锛氱鐢ㄩ櫝鑸�銆侀吀鎬ч鐗�锛屽皪(du矛)浜庣敤钘ュ姂閲忓拰鐢ㄨ棩娉ㄦ剰浜嬮爡(xi脿ng)锛屽ぇ瀹堕兘鎳�(y墨ng)瑭叉彁鍓嶄簡瑙ｆ竻妤氾紝骞朵笖鐢ㄨ棩鐨勬檪(sh铆)鍊欒鍤�(y谩n)鏍奸伒瀹堥€欎簺灏�(du矛)鐤剧梾鐨勬不鐧傞兘寰堥噸瑕�銆� 瑭虫儏
濂у崱瑗垮钩鐗囪捣濮嬪姂閲忓彲浠ョ偤涓€澶�600mg锛�8-10mg/kg/澶╋級锛屽垎鍏╂绲﹁棩锛岀従(xi脿n)鍦ㄩ€欑ó钘ュ搧閫氶亷(gu貌)鐩婅棩搴峰痉妯�(l猫)澶ц棩鎴垮氨鍙互璨�(m菐i)鍒�锛屽彟澶栦篃鏈夊叾浠栧嚭鍞湴榛�(di菐n)銆� 瑭虫儏
鍒╁繀閫氫笉鑹弽鎳�(y墨ng)锛氬湪鏈棩浣滅偤鍠棩娌荤檪鐨勮│椹�(y脿n)涓紝涓嶈壇鍙嶆噳(y墨ng)鐨勫牨(b脿o)灏�(d菐o)鍖呮嫭闋棝銆佺柌鍊︺€佺毊鐤�銆佹儭蹇冦€侀牠鏆�銆佸棞鐫″拰澶辩湢锛岃帛钘忥細璨棌浜�30掳C浠ヤ笅锛屼繚鎸佸共鐕ワ紝鎵€浠ラ€欑ó钘ョ墿浣跨敤閬�(gu貌)鍚庝篃鏄湁鍙兘鏈�(hu矛)灏�(d菐o)鑷寸梾浜哄嚭鐝�(xi脿n)涓€浜涗笉鑹弽鎳�(y墨ng)鐨�锛屽ぇ瀹剁敤钘ラ殠娈佃澶氭敞鎰忎竴涓嬨€� 瑭虫儏
寰�(f霉)鏂硅嫰宸存瘮濡ユ捍鍖栭垑鐗囩敤娉曠敤閲忥細鍙ｆ湇锛屾垚浜轰竴娆�1-2鐗囷紝涓€鏃�3娆�锛岀蹇岋細4.瀛曞│鍙婂摵涔虫湡濠﹀コ绂佺敤锛屾偅鑰呮湅鍙嬫噳(y墨ng)瑭叉寜鐓ф纰烘柟娉曟纰虹敤閲忛€�(j矛n)琛岃棩鐗╃殑浣跨敤锛屽皪(du矛)鐢ㄨ棩绂佸繉鐢ㄨ棩娉ㄦ剰浜嬮爡(xi脿ng)閮芥噳(y墨ng)瑭插毚(y谩n)鏍奸伒瀹�锛屽垏瑷樹笉瑕佸挤(qi谩ng)琛屼娇鐢ㄨ嚜宸卞苟涓嶉仼鍚堢殑钘ュ搧銆� 瑭虫儏
闁�(k膩i)娴﹁槶鐢ㄦ硶鐢ㄩ噺锛氾紙2锛夌郸钘ユ柟娉曞拰鍔戦噺锛氭垚浜猴紙>18姝诧級鍜岄潚灏戝勾锛�12-17姝诧級楂旈噸鈮�50kg璧峰娌荤檪鍔戦噺鐐烘瘡娆�500mg锛屾瘡鏃�2娆�锛岄棞(gu膩n)浜庣敤钘ユ儏娉侊紝鍦ㄨ(shu艒)鏄庢浉(sh奴)涓婂叾瀵�(sh铆)閮芥湁鍏烽珨浠嬬垂鐨�锛屽ぇ瀹剁敤钘ヤ箣鍓嶆噳(y墨ng)瑭蹭粩绱�(x矛)鏌ョ湅涓€涓嬶紝濡傛灉鏈変笉鎳傜殑鍦版柟锛岃涓诲嫊(d貌ng)璜�(q菒ng)鏁欏皥(zhu膩n)妤�(y猫)浜哄＋銆� 瑭虫儏
寰楃悊澶氱洰鍓嶅湪鐩婅棩搴峰痉妯�(l猫)澶ц棩鎴垮氨鏈夎常(m脿i)鐨�锛屽ぇ瀹跺彲浠ュ幓瑭茶棩鎴胯臣(g貌u)璨�(m菐i)钘ュ搧锛屾钘ョ墿鐢ㄤ簬4姝叉垨4姝蹭互涓嬪厭绔�锛屽垵濮嬪姂閲忓湪20-60mg/澶╋紝鐒跺悗闅旀棩澧炲姞20-60mg锛屽闀�(zh菐ng)瑕佸公鍔╁瀛愬毚(y谩n)鏍煎皣鐢ㄩ噺鎺у埗濂斤紝涓嶈闅ㄤ究瑾�(di脿o)鏁�銆� 瑭虫儏
涓欐垔閰搁垑绶╅噵鐗囧厭绔ユ湇鐢ㄦ湰钘ュ搧鏅�(sh铆)锛屽父瑕�(gu墨)鍔戦噺鐐烘瘡鏃�30mg/kg锛岃偛榻″│濂抽櫎闈炴槑纰洪渶瑕侊紙鍗冲湪鍏朵粬娌荤檪鐒�(w煤)鏁堟垨涓嶈兘鑰愬彈鐨勬儏娉佷笅锛夛紝鏈棩鍝佷笉瀹滃湪鑲查健濠﹀コ涓娇鐢�锛屾垜鍊戞噳(y墨ng)瑭插湪灏�(zhu膩n)妤�(y猫)閱�(y墨)鐢熸寚灏�(d菐o)涓嬪幓閬告搰娌荤檪鐧茬檱鐨勮棩鐗�锛屽苟涓斾篃瑕佹敞鎰忔纰虹殑鎿嶄綔鐩搁棞(gu膩n)娉ㄦ剰浜嬮爡(xi脿ng)瑕佽獚(r猫n)鐪熼伒瀹堛€� 瑭虫儏
姝ｅ搧淇濋殰 鏀惧績閬歌臣(g貌u)
鐢ㄨ棩鍏ㄧ▼鎸囧皫(d菐o)
寤犲鎺堟瑠(qu谩n) 姝ｅ搧娓犻亾
瀹夊叏鏀惧績 闅辩閰嶉€�
